Endocrine Abstracts

Introduction: Cushing’s disease (CD) is the most common cause of hypercortisolism. Therefore, the majority of studies focused on the efficacy and safety of novel steroidogenesis inhibitors included CD patients only. This is exactly the case with osilodrostat – new potent inhibitor of 11β-hydroxylase. However, approximately 10% of hypercortisolism result from cortisol-secreting adrenal adenoma. Data on potential differences in the treatment with osilodrostat betw...

Potassium bromate (KBrO3) is a known prooxidant and carcinogen. Melatonin is a highly effective antioxidant. Indole-3-propionic acid (IPA) – an indole substance, and propylothiouracil (PTU) – an antithyroid drug, also reveal some antioxidative effects. The aim of the study was to evaluate KBrO3-induced lipid peroxidation in vitro in tissues collected from either control or melatonin-treated rats, and to compare potential preventive effect...

Introduction: Graves’ disease (GD), similarly to most autoimmune disease, is triggered by environmental factors in genetically predisposed individuals. Particular HLA alleles increase or decrease GD risk. We have recently demonstrated novel, previously not reported association between a presence of alleles HLA-B*39:06, -B*37:01, -C*14:02, -C*03:02, -C*17:01, -DRB1*14:01 and GD. These alleles are independent risk factors, with no linkage disequilibrium with other,...

Introduction: Subacute thyroiditis is a thyroid inflammatory disease, triggered mainly by viral factors in genetically susceptible individuals. Up to 2020, only HLA-B*35 was confirmed as SAT-related. However, obviously in HLA-B*35-negative patients, some other genetic background occurs. Material and Methods: We performed HLA-typing using high resolution NGS method in different groups of patients with SAT and demonstrated the new association between HLA a...

Background: Copeptin, the C-terminal part of the arginine vasopressin (AVP) precursor, is a 39-amino acid peptide stoichiometrically secreted with AVP in 1:1 ratio from the posterior pituitary. In contrast to AVP, copeptin remains stable ex vivo for several days in serum or plasma. Here, we investigated the use of the copeptin assay in the diagnostic workup of patients with suspected anterior pituitary dysfunction.Patients and methods: We measur...

IntroductionDiagnostics of thyroid dysfunctions is frequently based on the measurements of TSH serum concentration only. Currently, due to a tendency to minimize stressful situations for a child (such as venipuncture to take a blood sample), some tests (i.e. TSH assessment) are performed at the Primary Healthcare Centre while other diagnostic tests (e.g. during an infection) are run. If TSH serum concentration is outside the reference range, it leads to ...